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Anaphase Promoting Complex Subunit 2 (ANAPC2)

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APC2; Cyclosome subunit 5

Anaphase Promoting Complex Subunit 2 (ANAPC2)
CCC L193
HGNC 19989
MGI 2139135
PubMed 21042722
RGD 1305546
UniProt Q9UJX6
Wiki ANAPC2
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans.
ANAPC2 is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 2 (ANAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 2 (ANAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 2 (ANAPC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 2 (ANAPC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit Customized Service Offer
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  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex."Mol. Biol. Cell 12:3839-3851(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Mitotic regulation of the human anaphase-promoting complex by phosphorylation."EMBO J. 22:6598-6609(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular architecture and mechanism of the anaphase-promoting complex."Nature 513:388-393(2014) [PubMed] [Europe PMC] [Abstract]