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Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B)

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APOBEC1L; ARCD3; ARP4; PHRBNL; A3B; Phorbolin 3; Phorbolin-1-related protein; DNA dC->dU-editing enzyme APOBEC-3B

Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B)
CCC L206
HGNC 17352
MGI 1933111
PubMed 23389445
RGD 1307800
UniProt Q9UH17
Wiki APOBEC3B
APOBEC3B is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. APOBEC3B is expressed primarily in peripheral blood leukocytes, and it was detected in most tumor cell lines examined.The deduced 235-amino acid, 28-kD protein is 89% identical to phorbolin-1, with most differences at the N terminus. Like phorbolin-1, phorbolin-1-related protein contains an RNA-editing region but fails to bind apolipoprotein B (APOB) mRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Polyclonal Antibody Customized Service Offer
Assay Kits SEL206Hu ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3B (APOBEC3B) ELISA Kit Customized Service Offer
  1. "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."J. Invest. Dermatol. 113:162-169(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G."AIDS Res. Hum. Retroviruses 21:611-619(2005) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."Genomics 79:285-296(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."Trends Genet. 19:207-216(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."Cell 114:21-31(2003) [PubMed] [Europe PMC] [Abstract]
  9. "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication."J. Biol. Chem. 279:53379-53386(2004) [PubMed] [Europe PMC] [Abstract]
  10. "APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."Curr. Biol. 16:480-485(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains."J. Biol. Chem. 281:36624-36631(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."PLoS Pathog. 2:E41-E41(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."Annu. Rev. Immunol. 26:317-353(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus."Curr. Opin. Infect. Dis. 21:298-303(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization."J. Virol. 82:9591-9599(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."Nucleic Acids Res. 38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
  17. "APOBEC3 proteins mediate the clearance of foreign DNA from human cells."Nat. Struct. Mol. Biol. 17:222-229(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."J. Virol. 85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."Front. Microbiol. 3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
  20. "APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."J. Virol. 86:6097-6108(2012) [PubMed] [Europe PMC] [Abstract]
  21. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Functions and regulation of the APOBEC family of proteins."Semin. Cell Dev. Biol. 23:258-268(2012) [PubMed] [Europe PMC] [Abstract]