≡

Beta-1,4-Galactosyltransferase 7 (b4GALT7)

[Edit]

B4GAL-T7; XGALT-1; XGALT1; XGPT1; beta4Gal-T7; Galactosyltransferase I; Xylosylprotein 4-beta-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7

Beta-1,4-Galactosyltransferase 7 (b4GALT7)
CCC L237
HGNC 930
MGI 2384987
PubMed 23956117
RGD 1309214
UniProt Q9UBV7
Wiki B4GALT7
Galactosyltransferase I is one of seven β-1,4-galactosyltransferase (β4GalT) enyzmes. These enzymes are type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-β-1,3-Gal-β-1,3-Gal-β-1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved β4GalT1-β4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 7 (b4GALT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 7 (b4GALT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 7 (b4GALT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 7 (b4GALT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 7 (b4GALT7) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family."J. Biol. Chem. 274:26165-26171(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans."J. Biol. Chem. 274:22915-22918(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structures of beta-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate Binding."J. Biol. Chem. 288:31963-31970(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene."J. Biol. Chem. 274:28841-28844(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]