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BRCA2 And CDKN1A Interacting Protein (BCCIP)

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TOK-1; P21- and CDK-associated protein 1

BRCA2 And CDKN1A Interacting Protein (BCCIP)
CCC L250
HGNC 978
MGI 1913415
PubMed 24145349
RGD 1307362
UniProt Q9P287
Wiki BCCIP
BCCIP was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21.
This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA2 And CDKN1A Interacting Protein (BCCIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA2 And CDKN1A Interacting Protein (BCCIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA2 And CDKN1A Interacting Protein (BCCIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA2 And CDKN1A Interacting Protein (BCCIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA2 And CDKN1A Interacting Protein (BCCIP) ELISA Kit Customized Service Offer
  1. "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase."J. Biol. Chem. 275:31145-31154(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the human BCCIP gene and its expression in cancer."Gene 302:139-146(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2."Oncogene 20:336-345(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Inhibition of G1 to S cell cycle progression by BCCIP beta."Cell Cycle 3:343-348(2004) [PubMed] [Europe PMC] [Abstract]
  9. "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1."Cell Cycle 3:1457-1462(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair."Mol. Cell. Biol. 25:1949-1957(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage."Nucleic Acids Res. 35:7160-7170(2007) [PubMed] [Europe PMC] [Abstract]
  13. "LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells."Biochem. Biophys. Res. Commun. 371:333-338(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]