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BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1)

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BACH1; OF; FANCJ; Fanconi Anemia Group J Protein; Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1-interacting protein C-terminal helicase 1

BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1)
CCC L266
HGNC 20473
MGI 2442836
PubMed 17033622
RGD 1307659
UniProt Q9BX63
Wiki BRIP1
BRIP1 is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
The predicted 1,249-amino acid BRIP1 protein contains the 7 helicase-specific motifs that are conserved among members of the DEAH family, and the helicase domain includes a nuclear localization signal. Northern blot analysis revealed ubiquitous expression of BRIP1, with highest levels in testis, an expression pattern similar to that of BRCA1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1) ELISA Kit Customized Service Offer
  1. "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function."Cell 105:149-160(2001) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The BRCT domain is a phospho-protein binding domain."Science 302:639-642(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations."Proc. Natl. Acad. Sci. U.S.A. 101:2357-2362(2004) [PubMed] [Europe PMC] [Abstract]
  7. "BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ."Cancer Cell 8:255-265(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair."Nat. Genet. 37:953-957(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response."PLoS Genet. 8:E1002786-E1002786(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling."Mol. Cell 14:405-412(2004) [PubMed] [Europe PMC] [Abstract]
  14. "No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22."Int. J. Cancer 98:638-639(2002) [PubMed] [Europe PMC] [Abstract]
  15. "No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families."Eur. J. Cancer 39:366-371(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."Hum. Mutat. 22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
  17. "The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia."Nat. Genet. 37:931-933(2005) [PubMed] [Europe PMC] [Abstract]
  18. "The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J."Nat. Genet. 37:934-935(2005) [PubMed] [Europe PMC] [Abstract]
  19. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes."Blood 116:3780-3791(2010) [PubMed] [Europe PMC] [Abstract]