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Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2)

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CAMKK; CAMKKB; Calcium/calmodulin-dependent protein kinase kinase beta

Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2)
CCC L286
HGNC 1470
MGI 2444812
PubMed 23583109
RGD 620092
UniProt Q96RR4
Wiki CAMKK2
CAMKK2belongs to the serine/threonine-specific protein kinase family, and to the Ca++/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4.
CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus. It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, through reduction in downstream signalling pathways and mu opioid receptor downregulation. Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL286Hu01 Recombinant Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL286Hu21 Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) WB; IHC; ICC; IP.
PAL286Hu01 Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) WB; IHC; ICC; IP.
Assay Kits SEL286Hu ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) ELISA Kit Customized Service Offer
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  3. "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells."FEBS Lett. 550:57-63(2003) [PubMed] [Europe PMC] [Abstract]
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  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase."J. Biomed. Sci. 5:141-149(1998) [PubMed] [Europe PMC] [Abstract]
  10. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation."RNA Biol. 8:1061-1072(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]