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Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1)

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Full of fluid protein homolog

Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1)
CCC L287
HGNC 29426
MGI 2445053
PubMed 24086631
RGD 1307670
UniProt Q6UXH8
Wiki CCBE1
CCBE1 is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumor suppressor.
By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2001) cloned CCBE1, which they designated KIAA1983.
The transcript contains a repetitive element in its 3-prime end, and the deduced protein contains 418 amino acids. RT-PCR ELISA detected highest expression in ovary and much lower expression in fetal liver and in adult lung, liver, and kidney. Much weaker expression was detected in all other adult and fetal tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen And Calcium Binding EGF Domain Containing Protein 1 (CCBE1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ccbe1 is required for embryonic lymphangiogenesis and venous sprouting."Nat. Genet. 41:396-398(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans."Nat. Genet. 41:1272-1274(2009) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Linkage and sequence analysis indicate that CCBE1 is mutated in recessively inherited generalised lymphatic dysplasia."Hum. Genet. 127:231-241(2010) [PubMed] [Europe PMC] [Abstract]
  9. ErratumHum. Genet. 127:243-243(2010)