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CD2 Associated Protein (CD2AP)

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CMS; Adapter protein CMS; Cas ligand with multiple SH3 domains

CD2 Associated Protein (CD2AP)
CCC L298
HGNC 14258
MGI 1330281
PubMed 22180476
RGD 727803
UniProt Q9Y5K6
Wiki CD2AP
CD2AP encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains.
The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.The cDNA corresponding to CMS encodes a protein of 639 amino acids with a deduced molecular mass of approximately 70 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL298Hu01 Recombinant CD2 Associated Protein (CD2AP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL298Hu01 Polyclonal Antibody to CD2 Associated Protein (CD2AP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for CD2 Associated Protein (CD2AP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Associated Protein (CD2AP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD2 Associated Protein (CD2AP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD2 Associated Protein (CD2AP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD2 Associated Protein (CD2AP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD2 Associated Protein (CD2AP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Associated Protein (CD2AP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL298Ra01 Recombinant CD2 Associated Protein (CD2AP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL298Ra01 Polyclonal Antibody to CD2 Associated Protein (CD2AP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for CD2 Associated Protein (CD2AP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Associated Protein (CD2AP) ELISA Kit Customized Service Offer
  1. "CMS: an adapter molecule involved in cytoskeletal rearrangements."Proc. Natl. Acad. Sci. U.S.A. 96:6211-6216(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction."J. Biol. Chem. 276:4957-4963(2001) [PubMed] [Europe PMC] [Abstract]
  6. "CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility."Science 300:1298-1300(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Clues to CD2-associated protein involvement in cytokinesis."Mol. Biol. Cell 16:2891-2902(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
  9. "CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP."J. Biol. Chem. 281:28919-28931(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
  11. "CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction."J. Neurosci. 28:8789-8800(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain."J. Biol. Chem. 281:38845-38853(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl."Biochim. Biophys. Acta 1774:35-43(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide from human RIN3."Submitted (DEC-2011) to the PDB data bank