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CD2 Binding Protein 2 (CD2BP2)

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FWP010; LIN1; Snu40; U5-52K; CD2 Antigen Cytoplasmic Tail-Binding Protein 2; U5 snRNP 52K protein

CD2 Binding Protein 2 (CD2BP2)
CCC L299
HGNC 1656
MGI 1917483
PubMed 25020258
RGD 1311741
UniProt O95400
Wiki CD2BP2
CD2BP2 encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7.
Alternative splicing results in multiple transcript variants but their biological validity has not been determined. The authors noted that a segment near the C terminus contains a consensus site for tyrosine phosphorylation. RNA blot analysis indicated that CD2BP2 is expressed in a wide variety of organs as approximately 1.35- and 4-kb transcripts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD2 Binding Protein 2 (CD2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD2 Binding Protein 2 (CD2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Binding Protein 2 (CD2BP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD2 Binding Protein 2 (CD2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD2 Binding Protein 2 (CD2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Binding Protein 2 (CD2BP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CD2 Binding Protein 2 (CD2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CD2 Binding Protein 2 (CD2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CD2 Binding Protein 2 (CD2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CD2 Binding Protein 2 (CD2BP2) ELISA Kit Customized Service Offer
  1. "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation."Proc. Natl. Acad. Sci. U.S.A. 95:14897-14902(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation."RNA 11:598-608(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Investigating the functional role of CD2BP2 in T cells."Int. Immunol. 19:1313-1318(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences."Nat. Struct. Biol. 6:656-660(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules."EMBO J. 21:5985-5995(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)."J. Mol. Biol. 369:902-908(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD."Nat. Commun. 5:3822-3822(2014) [PubMed] [Europe PMC] [Abstract]