Cellular Apoptosis Susceptibility Protein (CAS)
[Edit]CSE1L; XPO2; Exp2; CSE1 Chromosome Segregation 1-Like; Exportin-2; Chromosome segregation 1-like protein; Importin-alpha re-exporter
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Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind.
Cellular Apoptosis Susceptibility Protein binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cellular Apoptosis Susceptibility Protein (CAS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEL308Hu | ELISA Kit for Cellular Apoptosis Susceptibility Protein (CAS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cellular Apoptosis Susceptibility Protein (CAS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cellular Apoptosis Susceptibility Protein (CAS) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cellular Apoptosis Susceptibility Protein (CAS) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cellular Apoptosis Susceptibility Protein (CAS) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cellular Apoptosis Susceptibility Protein (CAS) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cellular Apoptosis Susceptibility Protein (CAS) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cellular Apoptosis Susceptibility Protein (CAS) | ELISA Kit Customized Service Offer |
- "Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1."Proc. Natl. Acad. Sci. U.S.A. 92:10427-10431(1995) [PubMed] [Europe PMC] [Abstract]
- "Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene."Genomics 58:41-49(1999) [PubMed] [Europe PMC] [Abstract]
- "IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells."Mol. Cell Biol. Res. Commun. 4:353-358(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]