≡

Centromere Protein M (CENPM)

[Edit]

CENP-M; PANE1; C22orf18; ICEN39; Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1

Centromere Protein M (CENPM)
CCC L312
HGNC 18352
MGI 1913820
PubMed 16622420
RGD 1307309
UniProt Q9NSP4
Wiki CENPM
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis.
CENPMcontains 180 amino acids. In silico analysis suggested that PANE1 was expressed predominantly in cancer tissues. Dot and Northern blot analyses revealed highest expression of a 1.2-kb transcript in fetal liver, thymus, and spleen, as well as in lymphoid cells and tumor cell lines, including B- and T-cell leukemias. PANE1 was expressed in activated, but not resting, B and T lymphocytes. Immunofluorescence microscopy showed nuclear localization of PANE1 in nonconfluent culture cells, but not in confluent or dividing cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein M (CENPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein M (CENPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein M (CENPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein M (CENPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein M (CENPM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein M (CENPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein M (CENPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein M (CENPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein M (CENPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein M (CENPM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein M (CENPM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein M (CENPM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein M (CENPM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein M (CENPM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein M (CENPM) ELISA Kit Customized Service Offer
  1. "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL."Blood 107:3779-3786(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells."Gene Expr. Patterns 4:389-395(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]