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Centromere Protein T (CENPT)

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CENP-T; C16orf56; ICEN22; Interphase centromere complex protein 22

Centromere Protein T (CENPT)
CCC L316
HGNC 25787
MGI 2443939
PubMed 8125298
RGD 1309383
UniProt Q96BT3
Wiki CENPT
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA replaces histone H3.
CENPT is an additional factor required for centromere assembly.Epitope-tagged CENPT bound to centromeres throughout interphase and during mitosis. CENPM, CENPN, CENPT, and CENPU (MLF1IP), together with CENPC and CENPH, bound CENPA in a nucleosome-associated complex. Small interference RNA (siRNA)-mediated depletion of CENPT disrupted recruitment of the core complex and caused an increase in the number of cells in mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein T (CENPT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein T (CENPT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein T (CENPT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein T (CENPT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein T (CENPT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein T (CENPT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein T (CENPT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein T (CENPT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein T (CENPT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein T (CENPT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein T (CENPT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein T (CENPT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein T (CENPT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein T (CENPT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein T (CENPT) ELISA Kit Customized Service Offer
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  9. "CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore."Cell 135:1039-1052(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B."J. Biophotonics 1:245-254(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes."Cell 145:410-422(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state."PLoS Biol. 9:E1001082-E1001082(2011) [PubMed] [Europe PMC] [Abstract]
  15. "CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold."Cell 148:487-501(2012) [PubMed] [Europe PMC] [Abstract]