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Centromere Protein S (CENPS)

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APITD1; CENP-S; MHF1; FAAP16; Apoptosis-Inducing,TAF9-Like Domain 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa

Centromere Protein S (CENPS)
CCC L320
HGNC 23163
MGI 1917178
PubMed 15197297
UniProt Q8N2Z9
APITD1, within a 500-kb neuroblastoma tumor suppressor candidate region on chromosome 1p36.22. Transcript A encodes a deduced 138-amino acid protein with a calculated molecular mass of 16 kD, and transcript B encodes a deduced 99-amino acid protein with a calculated molecular mass of 11 kD. Both proteins contain a TAF9-like domain. Northern blot analysis of neuroblastoma cell lines detected ubiquitous expression of a major, approximately 1.5 kb and a minor, less than 1 kb transcript.
Expression of transcript A was generally higher in fetal tissues, whereas that of transcript B was higher in adult tissues. Expression of both was significantly reduced in several primary neuroblastoma tumors and in tumors of varied tissue origin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein S (CENPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein S (CENPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein S (CENPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein S (CENPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein S (CENPS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centromere Protein S (CENPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centromere Protein S (CENPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centromere Protein S (CENPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centromere Protein S (CENPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centromere Protein S (CENPS) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours."Br. J. Cancer 91:1119-1130(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The human CENP-A centromeric nucleosome-associated complex."Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The CENP-S complex is essential for the stable assembly of outer kinetochore structure."J. Cell Biol. 186:173-182(2009) [PubMed] [Europe PMC] [Abstract]
  6. "A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability." Mol. Cell 37:865-878(2010)
  7. "MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM."Mol. Cell 37:879-886(2010)
  8. "CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold."Cell 148:487-501(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]