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Centaurin Gamma 3 (CENTg3)

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AGAP3; CRAG; MRIP-1; Arf-GAP With GTPase,ANK Repeat And PH Domain-Containing Protein 3; CRAM-associated GTPase; MR1-interacting protein

Centaurin Gamma 3 (CENTg3)
CCC L322
HGNC 16923
MGI 2183446
PubMed 16964243
RGD 1310751
UniProt Q96P47
Wiki CENTG3
D7S1277i is located in the intron of the AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; also known as CRAG) gene, a GTPase activating protein for ADP ribosylation factors. AGAP3 is a novel GTPase that accelerates the degradation of abnormally elongated polyglutamine proteins through intranuclear inclusion body formation. AGAP3 is induced by reactive oxygen species and inhibits the progression of polyglutamine disease. Although the association between AGAP3 and glaucoma is unclear, AGAP3 polymorphisms may act as risk factors in the development of NTG.
D7S1277i may be associated with other gene(s) but not AGAP3 since MS markers are highly polymorphic and generally show wide linkage disequilibriums within 100–200 kb .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 3 (CENTg3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 3 (CENTg3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 3 (CENTg3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 3 (CENTg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 3 (CENTg3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 3 (CENTg3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 3 (CENTg3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 3 (CENTg3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 3 (CENTg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 3 (CENTg3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centaurin Gamma 3 (CENTg3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centaurin Gamma 3 (CENTg3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centaurin Gamma 3 (CENTg3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centaurin Gamma 3 (CENTg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centaurin Gamma 3 (CENTg3) ELISA Kit Customized Service Offer
  1. "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins."Mol. Cell. Biol. 23:2476-2488(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase."J. Biol. Chem. 279:49346-49354(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein."J. Cell Biol. 172:497-504(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the Ras-like domain of CENTG3."Submitted (AUG-2009) to the PDB data bank