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Complement Factor H Related Protein 1 (CFHR1)

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CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2; H factor-like protein 1

Complement Factor H Related Protein 1 (CFHR1)
CCC L327
HGNC 4888
MGI 2138169
PubMed 23728178
UniProt Q03591
Wiki CFHR1
encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Factor H, via SCR domains 6 to 7 and 19 to 20, and FHR1, via SCR domains 3 to 5, bound to surface-expressed Pseudomonas aeruginosa elongation factor Tuf and also to recombinant Tuf. Factor H and plasminogen (PLG) bound simultaneously to Tuf, and PLG was proteolytically activated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL327Hu01 Recombinant Complement Factor H Related Protein 1 (CFHR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL327Hu21 Monoclonal Antibody to Complement Factor H Related Protein 1 (CFHR1) WB; IHC; ICC; IP.
PAL327Hu01 Polyclonal Antibody to Complement Factor H Related Protein 1 (CFHR1) WB; IHC; ICC; IP.
Assay Kits SEL327Hu ELISA Kit for Complement Factor H Related Protein 1 (CFHR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Factor H Related Protein 1 (CFHR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Factor H Related Protein 1 (CFHR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Factor H Related Protein 1 (CFHR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Factor H Related Protein 1 (CFHR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Factor H Related Protein 1 (CFHR1) ELISA Kit Customized Service Offer
  1. "Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule."J. Immunol. 146:3190-3196(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes."Mol. Immunol. 37:41-52(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Molecular cloning of a human serum protein structurally related to complement factor H."J. Biol. Chem. 266:12015-12020(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions."J. Immunol. 146:1265-1270(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?"Immunol. Today 15:121-126(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Dimerization of complement factor H-related proteins modulates complement activation in vivo."Proc. Natl. Acad. Sci. U.S.A. 110:4685-4690(2013) [PubMed] [Europe PMC] [Abstract]