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Complement Factor H Related Protein 2 (CFHR2)

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CFHL2; FHR2; HFL3; DDESK59; H factor-like protein 1

Complement Factor H Related Protein 2 (CFHR2)
CCC L328
HGNC 4890
PubMed 24260121
UniProt P36980
Wiki CFHR2
CFHR2 encodes a serum protein structurally and immunologically related to complement factor H (CFH). Skerka et al. (1995) isolated and characterized the CFHR2 gene from a YAC library.
Skerka et al. (1995) determined that the CFHR2 gene contains 5 exons and spans about 7 kb of genomic DNA.Skerka et al. (1995) demonstrated that the CFHR2 gene and the gene for the beta subunit of coagulation factor XIII (F13B) are located in the same 165-kb YAC DNA. Thus, the 3 structurally related genes F13B, CFHR2, and CFH are linked on chromosome 1 in the RCA (regulators of complement activation) gene cluster.The 5 factor H-related proteins have been identified and shown to be encoded by 5 genes, CFHR1, CFHR2, CFHR3 , CFHR4, and CFHR5, all closely linked to the CFH gene on chromosome 1q31-q32.1

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Factor H Related Protein 2 (CFHR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Factor H Related Protein 2 (CFHR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Factor H Related Protein 2 (CFHR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Factor H Related Protein 2 (CFHR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Factor H Related Protein 2 (CFHR2) ELISA Kit Customized Service Offer
  1. "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes."J. Immunol. 148:3313-3318(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene."Immunogenetics 42:268-274(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?"Immunol. Today 15:121-126(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Dimerization of complement factor H-related proteins modulates complement activation in vivo."Proc. Natl. Acad. Sci. U.S.A. 110:4685-4690(2013) [PubMed] [Europe PMC] [Abstract]