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Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1)

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ChGn; beta4GalNAcT; Chondroitin Beta 1,4 N-Acetylgalactosaminyltransferase

Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1)
CCC L335
HGNC 24290
MGI 2442354
PubMed 20812917
RGD 1307618
UniProt Q8TDX6
Wiki hChGn
CSGalNAcT-1 plays a critical role in CS biosynthesis in cartilage. By in situ hybridization and real time reverse transcription-PCR of developing cartilage, CSGalNAcT-1 exhibited the highest level of expression. Its expression in chondrogenic ATDC5 cells correlated well with that of aggrecan core protein. In heterozygote and homozygote aggrecannull cartilage where aggrecan transcription is decreased, CSGalNAcT-1 transcription diminished accordingly. Overexpression of the enzyme in chondrocytic cells further enhanced CS biosynthesis but not that of the aggrecan core protein, indicating that the enzyme activity is not saturated in the cells and that aggrecan synthesized in the overexpressing cells is heavier than the native molecule.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chondroitin Sulfate-N-Acetylgalactosaminyltransferase 1 (CSGALNACT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate."J. Biol. Chem. 277:8841-8846(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis."J. Biol. Chem. 277:38189-38196(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate."J. Biol. Chem. 278:3063-3071(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage."J. Biol. Chem. 282:4152-4161(2007) [PubMed] [Europe PMC] [Abstract]