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Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1)

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CIA1; WDR39; WD Repeat Domain 39; Probable cytosolic iron-sulfur protein assembly protein CIAO1

Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1)
CCC L339
HGNC 14280
MGI 1346998
PubMed 23150669
RGD 1307285
UniProt O76071
Wiki CIAO1
The Wilms tumor gene (WT1) on 11p13 is involved in regulating cell cycle progression and apoptosis. In an attempt to dissect the molecular mechanisms of transcriptional activation and repression by WT1, and to identify other proteins that may be involved in kidney and hematopoietic cell tumorigenesis, several groups have studied WT1-interacting proteins. WT1 also interacts with and regulates the transcriptional activity of steroidogenic factor-1, a key molecule in gonadal development.
CIAO1 is a 339-amino acid polypeptide containing 7 WD40 or beta-transducin repeats. It can inhibit the transcriptional activation function of WT1, but does not affect WT1-mediated transcriptional repression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Iron Sulfur Protein Assembly Protein 1 (CIAO1) ELISA Kit Customized Service Offer
  1. "Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1."J. Biol. Chem. 273:10880-10887(1998) [PubMed] [Europe PMC] [Abstract]
  2. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1."Immunogenetics 49:900-905(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis."Structure 15:1246-1257(2007) [PubMed] [Europe PMC] [Abstract]
  7. "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer."Acta Crystallogr. D 68:637-648(2012) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."Science 337:195-199(2012) [PubMed] [Europe PMC] [Abstract]
  12. "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."Science 337:243-245(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure and function of WD40 domain proteins."Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]