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C-Type Lectin Domain Family 2, Member A (CLEC2A)

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KACL; PILAR; Keratinocyte-Associated C-Type Lectin; Proliferation-Induced Lymphocyte-Associated Receptor

C-Type Lectin Domain Family 2, Member A (CLEC2A)
CCC L348
HGNC 24191
PubMed 20194751
UniProt Q6UVW9
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors. PILAR interacted with CD161 (KLRB1). RT-PCR analysis showed that T-cell activation induced transient expression of PILAR in CD8 T cells, and flow cytometric analysis demonstrated expression of PILAR on activated CD4 T cells. Increased expression of PILAR on antigen-presenting cells enhanced T-cell proliferation by increasing survival through enhanced expression of antiapoptotic proteins in a CD161-dependent manner.
PILAR was expressed by 7 to 10% of CD4 T cells from 2 samples of inflammatory synovial fluid, suggesting a role in joint inflammation pathogenesis.PILAR has a central role in modulating the extent of T-cell expansion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 2, Member A (CLEC2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 2, Member A (CLEC2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 2, Member A (CLEC2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 2, Member A (CLEC2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 2, Member A (CLEC2A) ELISA Kit Customized Service Offer
  1. "PILAR is a novel modulator of human T-cell expansion."Blood 112:1259-1268(2008) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family."Immunogenetics 59:903-912(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes."Proc. Natl. Acad. Sci. U.S.A. 107:5100-5105(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex."Proc. Natl. Acad. Sci. U.S.A. 110:11505-11510(2013) [PubMed] [Europe PMC] [Abstract]