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C-Type Lectin Domain Family 7, Member A (CLEC7A)

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BGR; CLECSF1; BGR; CANDF4; CLECSF12; DECTIN1; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1

C-Type Lectin Domain Family 7, Member A (CLEC7A)
CCC L353
HGNC 14558
MGI 1861431
PubMed 24393710
RGD 1565140
UniProt Q9BXN2
Wiki Dectin_1
CLEC7A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif.
It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 7, Member A (CLEC7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 7, Member A (CLEC7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 7, Member A (CLEC7A) Polyclonal Antibody Customized Service Offer
Assay Kits SEL353Hu ELISA Kit for C-Type Lectin Domain Family 7, Member A (CLEC7A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL353Mu01 Recombinant C-Type Lectin Domain Family 7, Member A (CLEC7A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL353Mu21 Monoclonal Antibody to C-Type Lectin Domain Family 7, Member A (CLEC7A) WB; IHC; ICC; IP.
Assay Kits SEL353Mu ELISA Kit for C-Type Lectin Domain Family 7, Member A (CLEC7A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 7, Member A (CLEC7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 7, Member A (CLEC7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 7, Member A (CLEC7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 7, Member A (CLEC7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 7, Member A (CLEC7A) ELISA Kit Customized Service Offer
  1. "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex."Eur. J. Immunol. 31:3493-3503(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1."Gene 272:51-60(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells."Immunogenetics 53:288-295(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the human beta-glucan receptor and its alternatively spliced isoforms."J. Biol. Chem. 276:43818-43823(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular and functional characterization of human Dectin-1."Exp. Hematol. 30:1309-1315(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM."Biochem. Biophys. Res. Commun. 347:1067-1073(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Dectin-1 promotes fungicidal activity of human neutrophils."Eur. J. Immunol. 37:467-478(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Human dectin-1 deficiency and mucocutaneous fungal infections." N. Engl. J. Med. 361:1760-1767(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity."Blood 116:5394-5402(2010) [PubMed] [Europe PMC] [Abstract]