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Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3)

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CRSP130; CRSP133; DRIP130; MED23; SUR2; Mediator of RNA polymerase II transcription subunit 23; Activator-recruited cofactor 130 kDa component

Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3)
CCC L379
HGNC 2372
MGI 1917458
PubMed 18544925
RGD 1307671
UniProt Q9ULK4
Wiki CRSP3
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. CRSP3 also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL379Hu01 Recombinant Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPL379Hu02 Recombinant Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Required For Sp1 Transcriptional Activation Subunit 3 (CRSP3) ELISA Kit Customized Service Offer
  1. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein."Nature 399:276-279(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  9. "TFIIH is negatively regulated by cdk8-containing mediator complexes."Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
  10. "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Ras induces mediator complex exchange on C/EBP beta."Mol. Cell 13:241-250(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  13. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."EMBO J. 29:1105-1115(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."Science 333:1161-1163(2011) [PubMed] [Europe PMC] [Abstract]