Cytochrome P450 2S1 (CYP2S1)

CYP2S1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.CYP2S1 contains an N-terminal hydrophobic stretch, a proline-rich region, and a conserved cysteine predicted to act as the heme iron ligand. CYP2S1 expression in trachea, lung, fetal lung, stomach, small intestine, and spleen, with lower expression in colon, appendix, liver, kidney, thymus, substantia nigra, peripheral leukocytes, and placenta.