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Cytochrome P450 4F3 (CYP4F3)

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CPF3; CYP4F; LTB4H; Leukotriene B4 Omega Hydroxylase; Cytochrome P450 Family 4 Subfamily F Polypeptide 3; 20-hydroxyeicosatetraenoic acid synthase

Cytochrome P450 4F3 (CYP4F3)
CCC L400
HGNC 2646
MGI 1919304
PubMed 11461919
RGD 1305261
UniProt Q08477
Wiki CYP4F3
CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away.
The deduced 520-amino acid LTB4H protein has a predicted molecular mass of 59,805 Da. It contains a cysteine in the conserved heme-binding domain near the C-terminus, which is a characteristic feature of the cytochrome P450 superfamily; the protein shares 31 to 44% similarity with CYP4A, CYP4B, and CYP4C.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 4F3 (CYP4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 4F3 (CYP4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 4F3 (CYP4F3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 4F3 (CYP4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 4F3 (CYP4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 4F3 (CYP4F3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 4F3 (CYP4F3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 4F3 (CYP4F3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 4F3 (CYP4F3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 4F3 (CYP4F3) ELISA Kit Customized Service Offer
  1. "A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase."J. Biol. Chem. 268:9376-9380(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization."DNA Cell Biol. 17:221-230(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase."J. Biol. Chem. 274:21191-21199(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Alternative splicing determines the function of CYP4F3 by switching substrate specificity."J. Biol. Chem. 276:38166-38172(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production."Prostaglandins Leukot. Essent. Fatty Acids 75:169-177(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism."J. Lipid Res. 49:2379-2389(2008) [PubMed] [Europe PMC] [Abstract]