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Disabled Homolog 2 Interacting Protein (DAB2IP)

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AIP1; AF9Q34; DIP1/2; nGAP-Like Protein; DOC-2/DAB2 Interactive Protein; ASK-Interacting Protein 1

Disabled Homolog 2 Interacting Protein (DAB2IP)
CCC L403
HGNC 17294
MGI 1916851
PubMed 20080667
RGD 621686
UniProt Q5VWQ8
Wiki DAB2IP
DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers.The deduced protein shares significant sequence identity with nGAP (RASAL2). RT-PCR ELISA detected intermediate to high expression in all adult and fetal tissues examined. Highest expression was detected in adult brain, adult kidney, and fetal brain. Within specific adult brain regions, highest expression was detected in cerebellum, hippocampus, caudate nucleus, substantia nigra, and subthalamic nucleus.The deduced 967-amino acid protein has a calculated molecular mass of 110 kD. The N-terminal half of DAB2IP contains a protein kinase C conserved region-2 (C2) domain and a RasGAP domain. The C-terminal half contains a proline-rich region and a leucine zipper domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Disabled Homolog 2 Interacting Protein (DAB2IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Disabled Homolog 2 Interacting Protein (DAB2IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Disabled Homolog 2 Interacting Protein (DAB2IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 Interacting Protein (DAB2IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 Interacting Protein (DAB2IP) ELISA Kit Customized Service Offer
  1. "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization."Genomics 79:573-581(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia."Genes Chromosomes Cancer 39:324-334(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3."J. Clin. Invest. 111:1933-1943(2003) [PubMed] [Europe PMC] [Abstract]
  8. "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."J. Biol. Chem. 279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation."J. Biol. Chem. 280:15061-15070(2005) [PubMed] [Europe PMC] [Abstract]
  10. "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."J. Biol. Chem. 282:14788-14796(2007) [PubMed] [Europe PMC] [Abstract]
  11. "AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation."Circ. Res. 102:840-848(2008) [PubMed] [Europe PMC] [Abstract]
  12. "AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice."J. Clin. Invest. 118:3904-3916(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis."Proc. Natl. Acad. Sci. U.S.A. 106:19878-19883(2009) [PubMed] [Europe PMC] [Abstract]
  15. "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."J. Biol. Chem. 285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]
  16. "An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB."Nat. Med. 16:286-294(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis."Proc. Natl. Acad. Sci. U.S.A. 107:2485-2490(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "AIP1 prevents graft arteriosclerosis by inhibiting interferon-gamma-dependent smooth muscle cell proliferation and intimal expansion."Circ. Res. 109:418-427(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival."Clin. Cancer Res. 18:4048-4058(2012) [PubMed] [Europe PMC] [Abstract]