≡

Decapping Enzyme 1B (DCP1B)

[Edit]

DCP1; hDcp1b

Decapping Enzyme 1B (DCP1B)
CCC L410
HGNC 24451
MGI 2442404
PubMed 12417715
RGD 1562214
UniProt Q8IZD4
Wiki DCP1B
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay . By searching for genes similar to S. cerevisiae Dcp1, Lykke-Andersen (2002) identified 2 distant human homologs, DCP1A and DCP1B. The deduced DCP1B protein contains 618 amino acids.
Mutation of asn20 and arg59 reduced DCP1A decapping activity by 4- and 12-fold, respectively, and both mutations resulted in reduced protein stability. Coimmunoprecipitation assays demonstrated that DCP1A and DCP2 interacted with the nonsense-mediated decay factor UPF1 (RENT1) both in the presence and in the absence of other UPF proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Decapping Enzyme 1B (DCP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Decapping Enzyme 1B (DCP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Decapping Enzyme 1B (DCP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Decapping Enzyme 1B (DCP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Decapping Enzyme 1B (DCP1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Decapping Enzyme 1B (DCP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Decapping Enzyme 1B (DCP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Decapping Enzyme 1B (DCP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Decapping Enzyme 1B (DCP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Decapping Enzyme 1B (DCP1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Decapping Enzyme 1B (DCP1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Decapping Enzyme 1B (DCP1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Decapping Enzyme 1B (DCP1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Decapping Enzyme 1B (DCP1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Decapping Enzyme 1B (DCP1B) ELISA Kit Customized Service Offer
  1. "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay."Mol. Cell. Biol. 22:8114-8121(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cytoplasmic foci are sites of mRNA decay in human cells."J. Cell Biol. 165:31-40(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]