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DEAH Box Polypeptide 9 (DHX9)

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DDX9; LKP; NDH2; NDH II; NDHII; RHA; Leukophysin; ATP-dependent RNA helicase A; DEAH(Asp-Glu-Ala-His)Box Polypeptide 9; Nuclear DNA helicase II

DEAH Box Polypeptide 9 (DHX9)
CCC L434
HGNC 2750
MGI 108177
PubMed 20510246
RGD 1308548
UniProt Q08211
Wiki DHX9
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
DHX9 encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 9 (DHX9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 9 (DHX9) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 9 (DHX9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 9 (DHX9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 9 (DHX9) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 9 (DHX9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 9 (DHX9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 9 (DHX9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 9 (DHX9) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 9 (DHX9) ELISA Kit Customized Service Offer
  1. "Human RNA helicase A is homologous to the maleless protein of Drosophila."J. Biol. Chem. 268:16822-16830(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles."J. Immunol. 156:2026-2035(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Domain structure of human nuclear DNA helicase II (RNA helicase A)."J. Biol. Chem. 272:11487-11494(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A functional interaction between the survival motor neuron complex and RNA polymerase II."J. Cell Biol. 152:75-85(2001) [PubMed] [Europe PMC] [Abstract]
  8. "RNA helicase A mediates association of CBP with RNA polymerase II."Cell 90:1107-1112(1997) [PubMed] [Europe PMC] [Abstract]
  9. "BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A."Nat. Genet. 19:254-256(1998) [PubMed] [Europe PMC] [Abstract]
  10. "The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain."Mol. Cell. Biol. 19:3540-3550(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Dual roles of RNA helicase A in CREB-dependent transcription."Mol. Cell. Biol. 21:4460-4469(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Antithetic effects of MBD2a on gene regulation."Mol. Cell. Biol. 23:2645-2657(2003) [PubMed] [Europe PMC] [Abstract]
  14. "RNA helicase A interacts with dsDNA and topoisomerase IIalpha."Nucleic Acids Res. 31:2253-2260(2003) [PubMed] [Europe PMC] [Abstract]
  15. "RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator."Eur. J. Biochem. 271:3741-3751(2004) [PubMed] [Europe PMC] [Abstract]
  16. "DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner."Nucleic Acids Res. 32:1-10(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Arginine methylation of RNA helicase a determines its subcellular localization."J. Biol. Chem. 279:22795-22798(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II."J. Biol. Chem. 280:9586-9594(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  20. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "An antiviral response directed by PKR phosphorylation of the RNA helicase A."PLoS Pathog. 5:E1000311-E1000311(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs."RNA 15:104-115(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs."RNA 18:321-334(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains."Biol. Chem. 394:1077-1090(2013) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein."J. Mol. Biol. 400:768-782(2010) [PubMed] [Europe PMC] [Abstract]