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DNA Replication Helicase 2 Like Protein (DNA2L)

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DNA replication ATP-dependent helicase/nuclease DNA2

DNA Replication Helicase 2 Like Protein (DNA2L)
CCC L440
HGNC 2939
MGI 2443732
PubMed 8938459
RGD 1306791
UniProt P51530
Wiki DNA2L
DNA2 interacted with mitochondrial DNA polymerase-gamma and significantly stimulated its polymerase activity. DNA2 and flap endonuclease-1 (FEN1) synergistically processed intermediate 5-prime flap structures occurring in DNA replication and long-patch base excision repair (LP-BER) in mitochondria.
The deduced 1,076-amino acid protein has a putative ATP/GTP-binding site motif A and a predicted transmembrane domain. Northern blot analysis detected low expression in KG-1 and HeLa cells and in thymus, but not in any other human tissue examined.Yeast Dna2 helicase is a DNA-dependent ATPase that unwinds duplex DNA to generate single-stranded DNA, which then acts as a template for DNA polymerization during DNA replication.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Replication Helicase 2 Like Protein (DNA2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Replication Helicase 2 Like Protein (DNA2L) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Replication Helicase 2 Like Protein (DNA2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Replication Helicase 2 Like Protein (DNA2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Replication Helicase 2 Like Protein (DNA2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Replication Helicase 2 Like Protein (DNA2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Replication Helicase 2 Like Protein (DNA2L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Replication Helicase 2 Like Protein (DNA2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Replication Helicase 2 Like Protein (DNA2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Replication Helicase 2 Like Protein (DNA2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Replication Helicase 2 Like Protein (DNA2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Replication Helicase 2 Like Protein (DNA2L) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of human Dna2 endonuclease and characterization of its enzymatic properties."Nucleic Acids Res. 34:1854-1864(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical analysis of human Dna2."Nucleic Acids Res. 34:1865-1875(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates."Mol. Cell 32:325-336(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Human Dna2 is a nuclear and mitochondrial DNA maintenance protein."Mol. Cell. Biol. 29:4274-4282(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates."J. Biol. Chem. 285:4398-4404(2010) [PubMed] [Europe PMC] [Abstract]
  9. "BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair."Genes Dev. 25:350-362(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2."J. Biol. Chem. 286:23763-23770(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication."J. Biol. Chem. 287:21980-21991(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1."Nucleic Acids Res. 40:6774-6786(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Genomic analysis of primordial dwarfism reveals novel disease genes."Genome Res. 24:291-299(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability." Am. J. Hum. Genet. 92:293-300(2013) [PubMed] [Europe PMC] [Abstract]