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Deoxyribonuclease I Like Protein 3 (DNASE1L3)

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DHP2; DNAS1L3; LSD; Deoxyribonuclease Gamma; Liver and spleen DNase; DNase I homolog protein DHP2

Deoxyribonuclease I Like Protein 3 (DNASE1L3)
CCC L441
HGNC 2959
MGI 1314633
PubMed 12974753
RGD 620669
UniProt Q13609
Wiki DNASE1L3
DNASE1L3 encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
The predicted 306-amino acid protein was 45% identical to that of DNASE1. Northern blot analysis showed that DNASE1L3 was expressed primarily in spleen and liver cells. The predominant mRNA was 1.3 kb, although there were 2 other transcripts. The purified recombinant protein had DNase activity in vitro that, unlike that of DNASE1, was not inhibited by G-actin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxyribonuclease I Like Protein 3 (DNASE1L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) Polyclonal Antibody Customized Service Offer
Assay Kits SEL441Hu ELISA Kit for Deoxyribonuclease I Like Protein 3 (DNASE1L3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL441Mu01 Recombinant Deoxyribonuclease I Like Protein 3 (DNASE1L3) Positive Control; Immunogen; SDS-PAGE; WB.
RPL441Mu02 Recombinant Deoxyribonuclease I Like Protein 3 (DNASE1L3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL441Mu01 Polyclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) WB; IHC; ICC; IP.
PAL441Mu02 Polyclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) WB; IHC; ICC; IP.
Assay Kits SEL441Mu ELISA Kit for Deoxyribonuclease I Like Protein 3 (DNASE1L3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxyribonuclease I Like Protein 3 (DNASE1L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxyribonuclease I Like Protein 3 (DNASE1L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxyribonuclease I Like Protein 3 (DNASE1L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease I Like Protein 3 (DNASE1L3) ELISA Kit Customized Service Offer
  1. "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I."Genomics 42:507-513(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a novel human DNase."Biochem. Biophys. Res. Commun. 231:499-504(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages."Gene 215:291-301(1998) [PubMed] [Europe PMC] [Abstract]
  4. "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein."Apoptosis 3:89-95(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus."Nat. Genet. 43:1186-1188(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]