≡

Diphthine Synthase (DPH5)

[Edit]

Diphthamide biosynthesis methyltransferase

Diphthine Synthase (DPH5)
CCC L446
HGNC 24270
MGI 1916990
PubMed 1508200
RGD 1307867
UniProt Q9H2P9
Wiki DPH5
DPH5 encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.The deduced protein contains 234 amino acids. DPH5 was expressed in all 5 human hematopoietic cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diphthine Synthase (DPH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diphthine Synthase (DPH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphthine Synthase (DPH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphthine Synthase (DPH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphthine Synthase (DPH5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diphthine Synthase (DPH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diphthine Synthase (DPH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphthine Synthase (DPH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphthine Synthase (DPH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphthine Synthase (DPH5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diphthine Synthase (DPH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diphthine Synthase (DPH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphthine Synthase (DPH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphthine Synthase (DPH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphthine Synthase (DPH5) ELISA Kit Customized Service Offer
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene."J. Biol. Chem. 288:12305-12312(2013) [PubMed] [Europe PMC] [Abstract]