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E2F Associated Phosphoprotein (EAPP)

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C14orf11

E2F Associated Phosphoprotein (EAPP)
CCC L457
HGNC 19312
MGI 1913516
PubMed 15716352
RGD 1309624
UniProt Q56P03
Wiki EAPP
EAPPencodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation.The deduced 281-amino acid protein has a calculated molecular mass of about 36 kD. EAPP contains several potential phosphorylation sites, and a shift in its apparent molecular mass following phosphatase treatment indicated that EAPP is phosphorylated. EAPP transcript in all tissues examined, with highest levels in heart, placenta, skeletal muscle, and pancreas, intermediate levels in brain, lung, and kidney, and low expression in liver. EAPP with or without the fluorescent tag was expressed almost exclusively in nuclei of transfected osteosarcoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Associated Phosphoprotein (EAPP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Associated Phosphoprotein (EAPP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Associated Phosphoprotein (EAPP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Associated Phosphoprotein (EAPP) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Associated Phosphoprotein (EAPP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Associated Phosphoprotein (EAPP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Associated Phosphoprotein (EAPP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Associated Phosphoprotein (EAPP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Associated Phosphoprotein (EAPP) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Associated Phosphoprotein (EAPP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Associated Phosphoprotein (EAPP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Associated Phosphoprotein (EAPP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Associated Phosphoprotein (EAPP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Associated Phosphoprotein (EAPP) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Associated Phosphoprotein (EAPP) ELISA Kit Customized Service Offer
  1. "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes."Genomics 85:608-621(2005) [PubMed] [Europe PMC] [Abstract]
  2. "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription."Mol. Biol. Cell 16:2181-2190(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]