≡

Endogenous Retroviral Family W, Env Member 1 (ERVWE1)

[Edit]

Env-W; HERV-7q; HERV-W; HERV-W-ENV; HERVW; Envelope Protein; HERV-W Env Glycoprotein; Enverin; Syncytin-1; HERV-Tryptophan Envelope Protein; Envelope Glycoprotein

Endogenous Retroviral Family W, Env Member 1 (ERVWE1)
CCC L471
HGNC 13525
PubMed 24478419
UniProt Q9UQF0
Wiki ERVWE1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction.
ERVWE1 is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endogenous Retroviral Family W, Env Member 1 (ERVWE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endogenous Retroviral Family W, Env Member 1 (ERVWE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endogenous Retroviral Family W, Env Member 1 (ERVWE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endogenous Retroviral Family W, Env Member 1 (ERVWE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endogenous Retroviral Family W, Env Member 1 (ERVWE1) ELISA Kit Customized Service Offer
  1. "Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family."J. Virol. 73:1175-1185(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Syncytin is captive retroviral envelope protein involved in human placental morphogenesis."Nature 403:785-789(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family."AIDS Res. Hum. Retroviruses 16:731-740(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology."Proc. Natl. Acad. Sci. U.S.A. 101:1731-1736(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The HERV-W/7q family in the human genome. Potential for protein expression and gene regulation."Cell. Mol. Biol. 48:213-217(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Endogenous retroviruses and multiple sclerosis. II. HERV-7q."C. R. Acad. Sci. III, Sci. Vie 321:857-863(1998) [PubMed] [Europe PMC] [Abstract]
  9. "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor."J. Virol. 74:3321-3329(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope."J. Virol. 75:3488-3489(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation."Virology 287:321-332(2001) [PubMed] [Europe PMC] [Abstract]
  12. "The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors."J. Virol. 76:6442-6452(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution."Proc. Natl. Acad. Sci. U.S.A. 100:13013-13018(2003) [PubMed] [Europe PMC] [Abstract]
  14. "The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus."Arch. Virol. 148:659-675(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins."J. Virol. 77:10414-10422(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta."Biol. Reprod. 69:286-293(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation."Mol. Biol. Evol. 21:1895-1901(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination."Nat. Neurosci. 7:1088-1095(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope."J. Virol. 79:5585-5593(2005) [PubMed] [Europe PMC] [Abstract]
  20. "A novel human endogenous retroviral protein inhibits cell-cell fusion."Sci. Rep. 3:1462-1462(2013) [PubMed] [Europe PMC] [Abstract]