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Zinc Phosphodiesterase ELAC Protein 2 (ELAC2)

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HPC2; ELC2; tRNase Z,Long Form; ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2

Zinc Phosphodiesterase ELAC Protein 2 (ELAC2)
CCC L489
HGNC 14198
MGI 1890496
PubMed 21593607
RGD 628882
UniProt Q9BQ52
Wiki ELAC2
ELAC2 has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Phosphodiesterase ELAC Protein 2 (ELAC2) ELISA Kit Customized Service Offer
  1. "A candidate prostate cancer susceptibility gene at chromosome 17p." Nat. Genet. 27:172-180(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease."Nucleic Acids Res. 31:2272-2278(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "RNA processing in human mitochondria."Cell Cycle 10:2904-2916(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs."RNA Biol. 8:616-626(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Association of HPC2/ELAC2 genotypes and prostate cancer."Am. J. Hum. Genet. 67:1014-1019(2000) [PubMed] [Europe PMC] [Abstract]
  13. "ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer."Cancer Res. 61:6038-6041(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Role of HPC2/ELAC2 in hereditary prostate cancer."Cancer Res. 61:6494-6499(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Association of common missense changes in ELAC2 (HPC2) with prostate cancer in a Japanese case-control series."J. Hum. Genet. 47:641-648(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer."Am. J. Hum. Genet. 71:1475-1478(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Ser217Leu polymorphism of the HPC2/ELAC2 gene associated with prostatic cancer risk in Japanese men."Int. J. Cancer 107:224-228(2003) [PubMed] [Europe PMC] [Abstract]
  18. "ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer."J. Natl. Cancer Inst. 95:818-824(2003) [PubMed] [Europe PMC] [Abstract]
  19. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
  20. "ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy."Am. J. Hum. Genet. 93:211-223(2013) [PubMed] [Europe PMC] [Abstract]