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Myoferlin (MYOF)

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FER1L3; Fer-1-Like 3

Myoferlin (MYOF)
CCC L518
HGNC 3656
MGI 1919192
PubMed 23864327
RGD 1564216
UniProt Q9NZM1
Wiki FER1L3
MYOF encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length natures have not been determined.
Expressed in myoblast and endothelial cells (at protein level). Highly expressed in cardiac and skeletal muscles. Also present in lung, and at very low levels in kidney, placenta and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL518Hu01 Recombinant Myoferlin (MYOF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Myoferlin (MYOF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myoferlin (MYOF) Polyclonal Antibody Customized Service Offer
Assay Kits SEL518Hu ELISA Kit for Myoferlin (MYOF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myoferlin (MYOF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myoferlin (MYOF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myoferlin (MYOF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myoferlin (MYOF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myoferlin (MYOF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myoferlin (MYOF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myoferlin (MYOF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myoferlin (MYOF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myoferlin (MYOF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myoferlin (MYOF) ELISA Kit Customized Service Offer
  1. "Myoferlin, a candidate gene and potential modifier of muscular dystrophy."Hum. Mol. Genet. 9:217-226(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The third human FER-1-like protein is highly similar to dysferlin."Genomics 68:313-321(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains."J. Biol. Chem. 277:22883-22888(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function."J. Biol. Chem. 282:30745-30753(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion."J. Biol. Chem. 283:20252-20260(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation."FASEB J. 28:2955-2969(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b."J. Mol. Biol. 379:981-990(2008) [PubMed] [Europe PMC] [Abstract]