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Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE)

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PIP5K3; CFD; PIP5K; PIKfyve; p235; Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase,Type III; 1-phosphatidylinositol 3-phosphate 5-kinase

Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE)
CCC L531
HGNC 23785
MGI 1335106
PubMed 23154468
RGD 1592067
UniProt Q9Y2I7
Wiki PIKFYVE
PIKFYVE make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Polyclonal Antibody Customized Service Offer
Assay Kits SEL531Hu ELISA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL531Mu01 Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL531Mu01 Polyclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve endomembrane localization."J. Biol. Chem. 277:6073-6079(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex."J. Biol. Chem. 282:23878-23891(2007) [PubMed] [Europe PMC] [Abstract]
  9. "ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality."J. Mol. Biol. 384:766-779(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of PIKfyve phosphorylation by insulin and osmotic stress."Biochem. Biophys. Res. Commun. 397:650-655(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in PIP5K3 are associated with Francois-Neetens mouchetee fleck corneal dystrophy."Am. J. Hum. Genet. 77:54-63(2005) [PubMed] [Europe PMC] [Abstract]