≡

Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1)

[Edit]

CDH1; CDC20C; FZR; FZR2; HCDH; HCDH1; CDC20-like protein 1; Cdh1/Hct1 homolog

Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1)
CCC L532
HGNC 24824
MGI 1926790
PubMed 24553289
RGD 1308713
UniProt Q9UM11
Wiki FZR1
Activation of the anaphase-promoting complex (APC) is required for anaphase initiation and for exit from mitosis. Fang et al. (1998) showed that APC is activated during mitosis and G1 by 2 regulatory factors, CDC20 and HCDH1. These proteins directly bind to APC and activate its cyclin ubiquitination activity. CDC20 confers a strict destruction box (D box) dependence on APC, while HCDH1 shows a much more relaxed specificity for the D box. HCDH1 contains WD40 repeats and is more closely related to yeast CDH1/HCT1 and Xenopus and Drosophila fzr, with which it shows 36%, 96%, and 69% sequence identity, respectively. In HeLa cells, the HCDH1 protein levels remain constant during the cell cycle and may target specific substrates lacking the D box in G1, such as polo-like kinase, for ubiquitination.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fizzy/Cell Division Cycle 20 Related Protein 1 (FZR1) ELISA Kit Customized Service Offer
  1. "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family."Curr. Biol. 8:1207-1210(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1."Biochem. J. 374:349-358(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1."Mol. Cell 2:163-171(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of APC activity by phosphorylation and regulatory factors."J. Cell Biol. 146:791-800(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1."Genes Dev. 15:1759-1764(2001) [PubMed] [Europe PMC] [Abstract]
  9. "MAD2B is an inhibitor of the anaphase-promoting complex."Genes Dev. 15:1765-1770(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex."J. Biol. Chem. 282:17712-17719(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint."Cell 134:256-267(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."Mol. Cell 42:511-523(2011) [PubMed] [Europe PMC] [Abstract]
  16. "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."Cancer Cell 20:487-499(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1)."Oncogene 31:2907-2918(2012) [PubMed] [Europe PMC] [Abstract]