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Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)

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DDIT1; GADD45; DNA damage-inducible transcript 1 protein

Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a)
CCC L534
HGNC 4095
MGI 107799
PubMed 17268471
RGD 2654
UniProt P24522
Wiki GADD45A
GADD45a is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
GADD45 is the only known x-ray responsive gene whose induction is not mediated by PKC. Sequence analysis of human and hamster cDNA clones demonstrated that the gene has been highly conserved and encodes a novel 165-amino acid polypeptide that is 96% identical in the 2 species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL534Hu01 Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL534Hu01 Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) WB; IHC; ICC; IP.
MAL534Hu21 Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) WB; IHC; ICC; IP.
Assay Kits SEL534Hu ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL534Ra01 Recombinant Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Positive Control; Immunogen; SDS-PAGE; WB.
APL534Ra01 Active Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Cell culture; Activity Assays.
Antibodies PAL534Ra01 Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) WB; IHC; ICC; IP.
MAL534Ra21 Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) WB; IHC; ICC; IP.
Assay Kits SEL534Ra ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Alpha (GADD45a) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C."Mol. Cell. Biol. 11:1009-1016(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the mammalian gadd45 gene and its response to DNA damage."J. Biol. Chem. 268:24385-24393(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA."Nucleic Acids Res. 34:485-495(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen."Science 266:1376-1380(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase."J. Biol. Chem. 285:22196-22201(2010) [PubMed] [Europe PMC] [Abstract]