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Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1)

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GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1; GDNF family receptor alpha-1; TGF-beta-related neurotrophic factor receptor 1

Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1)
CCC L548
HGNC 4243
MGI 1100842
PubMed 22056784
RGD 2681
UniProt P56159
GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. RET stimulation in trans by soluble or immobilized GFRA1 potentiates downstream signaling, neurite outgrowth, and neuronal survival, and elicits dramatic localized expansions of axons and growth cones.
Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase. Activated RET associates with different adaptor proteins inside and outside lipid rafts. The authors concluded that these results provide an explanation of the tissue distribution of GFRA1, supporting the physiologic importance of RET activation in trans as a mechanism to potentiate and diversify the biologic responses to GDNF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL548Hu01 Recombinant Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL548Hu01 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) WB; IHC; ICC; IP.
LAL548Hu71 Biotin-Linked Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) WB; IHC; ICC.
MAL548Hu21 Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) WB; IHC; ICC; IP.
Assay Kits SEL548Hu ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL548Mu01 Recombinant Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL548Mu01 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 1 (GFRa1) ELISA Kit Customized Service Offer
  1. "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF."Cell 85:1113-1124(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins."Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility."Genomics 48:354-362(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Mutational analysis of the GDNF/RET-GDNFR-alpha signaling complex in a kindred with vesicoureteral reflux."Hum. Genet. 102:474-478(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular analysis of congenital central hypoventilation syndrome."Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]