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Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3)

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GDNF family receptor alpha-3

Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3)
CCC L549
HGNC 4245
MGI 1201403
PubMed 12624147
RGD 620502
UniProt O60609
Wiki GFRA3
GFRa3is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
The gene has 8 coding exons and a gene structure and organization similar to that of GFRA1. The authors identified 3 polymorphic variants in GFRA3 in a normal control population and found the same variants in patients with Hirschsprung disease, but found no correlation between these variants and the Hirschsprung disease phenotype.GFRA3 does not form a signaling receptor complex with RET for GDNF, NRTN, or PSPN .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APL549Mu61 Active Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRa3) ELISA Kit Customized Service Offer
  1. "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family."Proc. Natl. Acad. Sci. U.S.A. 95:5801-5806(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex."Neuron 21:1291-1302(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors."Structure 14:1083-1092(2006) [PubMed] [Europe PMC] [Abstract]