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GTPase, IMAP Family, Member 1 (GIMAP1)

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HIMAP1; IMAP1; Immunity-associated protein 1

GTPase, IMAP Family, Member 1 (GIMAP1)
CCC L553
HGNC 23237
MGI 109368
RGD 1306777
UniProt Q8WWP7
The deduced 306-amino acid protein has a calculated molecular mass of 34.3 kD. IMAP1 contains an N-terminal RK endoplasmic reticulum (ER) retention signal, 5 motifs conserved in GTP-binding proteins, and a putative C-terminal transmembrane region. IMAP1 shares 43 to 46% identity with IMAP2, IMAP3 (IAN4L1), and IMAP4. Multiple-tissue expression array analysis detected predominant expression of IMAP1 in spleen and lower expression in lymph nodes. Transient transfection of Chinese hamster ovary cells resulted in colocalization of IMAP1 with ER resident proteins.
IMAP1 gene contains 3 exons. Exon 1 is untranslated, and exon 3 contains more than 94% of the coding sequence. The 5-prime flanking region of IMAP1 has several silencing elements.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase, IMAP Family, Member 1 (GIMAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase, IMAP Family, Member 1 (GIMAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GTPase, IMAP Family, Member 1 (GIMAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GTPase, IMAP Family, Member 1 (GIMAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GTPase, IMAP Family, Member 1 (GIMAP1) ELISA Kit Customized Service Offer
  1. "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36."Gene 282:159-167(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural insights into the mechanism of GTPase activation in the GIMAP family."Structure 21:550-559(2013) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of human GTPase IMAP family member 1."Submitted (MAR-2010) to the PDB data bank
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]