≡

Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1)

[Edit]

G10P1; GARG-16; IFI-56; IFI56; IFNAI1; ISG56; RNM561; Interferon-induced 56 kDa protein

Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1)
CCC L609
HGNC 5407
MGI 2148249
PubMed 21642987
RGD 620599
UniProt P09914
Wiki IFIT1
Treatment of responsive cells with interferons induces, within a few hours, a rise in the concentration of several mRNAs and proteins.An induced mRNA of about 2 kb, termed C56, was found to code for a 56-kD protein easily detected by hybridization-translation experiments. ISG56 overexpression inhibited virus-triggered activation of interferon-stimulated regulatory element (ISRE), a conserved enhancer motif recognized by activated IRF3, and the IFNB promoter. In contrast, ISG56 knockdown potentiated virus-induced activation of ISRE, NFKB, and IFNB. ISG56 interaction with MITA inhibited MITA interaction with VISA (MAVS) and TBK1. ISG56 is a mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons."Eur. J. Biochem. 155:11-17(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA."Nucleic Acids Res. 11:1213-1226(1983) [PubMed] [Europe PMC] [Abstract]
  6. "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes."Eur. J. Biochem. 169:313-321(1987) [PubMed] [Europe PMC] [Abstract]
  7. "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family."FEBS Lett. 231:164-171(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways."Proc. Natl. Acad. Sci. U.S.A. 102:10200-10205(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54."Virology 340:116-124(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1."EMBO J. 27:3311-3321(2008) [PubMed] [Europe PMC] [Abstract]
  11. "ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response."Proc. Natl. Acad. Sci. U.S.A. 106:7945-7950(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells."DNA Cell Biol. 30:671-679(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The interferon stimulated gene 54 promotes apoptosis."J. Biol. Chem. 286:7257-7266(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The ISG56/IFIT1 gene family."J. Interferon Cytokine Res. 31:71-78(2011) [PubMed] [Europe PMC] [Abstract]
  16. "ISG56 and IFITM1 proteins inhibit hepatitis C virus replication."J. Virol. 85:12881-12889(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Where, in antiviral defense, does IFIT1 fit?"Nat. Immunol. 12:588-590(2011) [PubMed] [Europe PMC] [Abstract]
  18. "IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA."Nat. Immunol. 12:624-630(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins."Nature 494:60-64(2013) [PubMed] [Europe PMC] [Abstract]