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Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3)

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MP-3; IMP3; KOC1; VICKZ3; CT98; IGF II mRNA Binding Protein 3; Cancer/Testis Antigen 98; KH domain-containing protein overexpressed in cancer

Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3)
CCC L617
HGNC 28868
MGI 1890359
PubMed 22840368
RGD 1306512
UniProt O00425
Wiki IGF2BP3
IGF2BP3 is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL617Hu01 Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL617Hu01 Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) WB; IHC; ICC; IP.
MAL617Hu21 Monoclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) WB; IHC; ICC; IP.
Assay Kits SEL617Hu ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCL617Hu CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) ELISA Kit Customized Service Offer
  1. "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein."Oncogene 14:2729-2733(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of the highly conserved RNA binding protein KOC in embryogenesis."Mech. Dev. 88:95-99(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development."Mol. Cell. Biol. 19:1262-1270(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies."Clin. Immunol. 100:149-156(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome."J. Med. Genet. 39:575-581(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear transit of human zipcode-binding protein IMP1."Biochem. J. 376:383-391(2003) [PubMed] [Europe PMC] [Abstract]
  10. "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins."Biol. Cell 97:87-96(2005) [PubMed] [Europe PMC] [Abstract]
  11. "KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas."Diagn. Mol. Pathol. 29:188-195(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer."Reproduction 130:203-212(2005) [PubMed] [Europe PMC] [Abstract]
  13. "RNA-binding IMPs promote cell adhesion and invadopodia formation."EMBO J. 25:1456-1468(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study."Lancet Oncol. 7:556-564(2006) [PubMed] [Europe PMC] [Abstract]
  15. "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression."Mod. Pathol. 20:242-247(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "ZBP1 recognition of beta-actin zipcode induces RNA looping."Genes Dev. 24:148-158(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains."Biol. Chem. 394:1077-1090(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of RNA binding domain in insulin-like growth factor 2 mRNA-binding protein 3."Submitted (JUN-2007) to the PDB data bank