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Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP)

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PP2C-DELTA

Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP)
CCC L622
HGNC 15566
MGI 1914694
PubMed 11331582
RGD 620128
UniProt Q9H0C8
Wiki ILKAP
ILKAP is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Linked Kinase Associated Serine/Threonine Phosphatase 2C (ILKAP) ELISA Kit Customized Service Offer
  1. "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1."EMBO J. 20:2160-2170(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ILKAP regulates ILK signaling and inhibits anchorage-independent growth."Oncogene 23:3454-3461(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]