Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B)
[Edit]OCRL2; 75 kDa inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase; Type II inositol 1,4,5-trisphosphate 5-phosphatase
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases. INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.It is one of at least 3 enzymes known to catalyze the conversion of inositol-1,4,5-trisphosphate (IP3) to inositol-1,4-bisphosphate (IP2). Three enzymes with this activity were identified: a 45-kD polypeptide, a 75-kD polypeptide, and a 120-kD polypeptide.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Inositol Polyphosphate-5-Phosphatase 75kDa (INPP5B) | ELISA Kit Customized Service Offer |
- "Properties of type II inositol polyphosphate 5-phosphatase."J. Biol. Chem. 270:9370-9377(1995) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase."J. Biol. Chem. 266:20283-20289(1991) [PubMed] [Europe PMC] [Abstract]
- "Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway."J. Cell Sci. 120:3941-3951(2007) [PubMed] [Europe PMC] [Abstract]
- "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1."Proc. Natl. Acad. Sci. U.S.A. 107:3511-3516(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway."Mol. Biol. Cell 22:606-623(2011) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of INPP5B in complex with phosphatidylinositol 4-phosphate (CASP target)."Submitted (JUL-2010) to the PDB data bank