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MAF1 Homolog (MAF1)

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Repressor of RNA polymerase III transcription MAF1 homolog

MAF1 Homolog (MAF1)
CCC L690
HGNC 24966
MGI 1916127
PubMed 20233713
RGD 1359315
UniProt Q9H063
Wiki MAF1
MAF1 encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.MAF1 targeted an ELK1-binding site in the TBP promoter, and binding at this site was reciprocal with that of ELK1. Similarly, MAF1 occupancy of pol III genes was inversely correlated with that of the initiation factor TFIIIB and pol III. The phenotypic consequences of reducing MAF1 expression included changes in cell morphology and accumulation of actin stress fibers, whereas MAF1 overexpression suppressed anchorage-independent growth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAF1 Homolog (MAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAF1 Homolog (MAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAF1 Homolog (MAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAF1 Homolog (MAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAF1 Homolog (MAF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAF1 Homolog (MAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAF1 Homolog (MAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAF1 Homolog (MAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAF1 Homolog (MAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAF1 Homolog (MAF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAF1 Homolog (MAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAF1 Homolog (MAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAF1 Homolog (MAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAF1 Homolog (MAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAF1 Homolog (MAF1) ELISA Kit Customized Service Offer
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  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2."Int. J. Biol. Sci. 3:292-302(2007) [PubMed] [Europe PMC] [Abstract]
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  8. "Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells."J. Biol. Chem. 285:15380-15392(2010) [PubMed] [Europe PMC] [Abstract]
  9. "mTORC1 directly phosphorylates and regulates human MAF1."Mol. Cell. Biol. 30:3749-3757(2010) [PubMed] [Europe PMC] [Abstract]
  10. "mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1."Proc. Natl. Acad. Sci. U.S.A. 107:11823-11828(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression."J. Biol. Chem. 288:19288-19295(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]