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Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2)

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TAB2; TGF-Beta Bctivated Kinase 1/MAP3K7 Binding Protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2

Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2)
CCC L704
HGNC 17075
MGI 1915902
PubMed 19675569
RGD 1309527
UniProt Q9NYJ8
Wiki MAP3K7IP2
MAP3K7IP2is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.Sequence analysis predicted that the TAB2 protein contains 693 amino acids and has a molecular mass of 77 kD. One distinctive feature of the TAB2 protein is the presence of amino acids (residues 535 to 609) that have the potential to form an amphipathic alpha helix (coiled-coil structure).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) ELISA Kit Customized Service Offer
  1. "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway."Mol. Cell 5:649-658(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."EMBO J. 22:6277-6288(2003) [PubMed] [Europe PMC] [Abstract]
  10. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
  11. "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation."Cell. Signal. 20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."Cell. Mol. Life Sci. 66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Direct activation of protein kinases by unanchored polyubiquitin chains."Nature 461:114-119(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Haploinsufficiency of TAB2 causes congenital heart defects in humans."Am. J. Hum. Genet. 86:839-849(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "TRIM5 is an innate immune sensor for the retrovirus capsid lattice."Nature 472:361-365(2011) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of the N-terminal CUE domain in the human mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (MAP3K7IP2)."Submitted (FEB-2007) to the PDB data bank
  21. "Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain."Nat. Struct. Mol. Biol. 16:1328-1330(2009) [PubMed] [Europe PMC] [Abstract]