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Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1)

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MICAL; MICAL-1; NICAL; NEDD9 Interacting Protein With Calponin Homology And LIM Domains; Molecule interacting with CasL protein 1

Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1)
CCC L729
HGNC 20619
MGI 2385847
PubMed 12788069
RGD 1309386
UniProt Q8TDZ2
Wiki MICAL1
The 118-kD, 1,067-amino acid MICAL protein has a calponin homology domain, a LIM domain, a putative leucine zipper motif, and a proline-rich PPKPP sequence. MICAL associates with CASL through the PPKPP sequence. Northern blot analysis of hematopoietic cell lines and murine tissues showed that MICAL is expressed in thymus, lung, spleen, kidney, testis, and hematopoietic cells. MICAL is a cytoplasmic protein that colocalizes with CASL at the perinuclear area. Through its C-terminal region, MICAL also associates with vimentin , a major component of intermediate filaments. Immunostaining revealed that MICAL localizes along with vimentin intermediate filaments. These results suggested that MICAL may be a cytoskeletal regulator that connects CASL to intermediate filaments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing Protein 1 (MICAL1) ELISA Kit Customized Service Offer
  1. "MICAL, a novel CasL interacting molecule, associates with vimentin."J. Biol. Chem. 277:14933-14941(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of long cDNA clones from human adult spleen."DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."Cell 109:887-900(2002) [PubMed] [Europe PMC] [Abstract]
  8. "MICAL-1 isoforms, novel rab1 interacting proteins."Biochem. Biophys. Res. Commun. 306:79-86(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The MICAL proteins and rab1: a possible link to the cytoskeleton?"Biochem. Biophys. Res. Commun. 328:415-423(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein."J. Neurosci. 28:2287-2297(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1."Arch. Biochem. Biophys. 515:1-13(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."Cell 156:563-576(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the CH domain of human NEDD9-interacting protein with calponin homology and LIM domains."Submitted (AUG-2005) to the PDB data bank
  18. "Solution structure of calponin homology domain of Human MICAL-1."J. Biomol. NMR 36:295-300(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain."Biophys. Chem. 129:269-278(2007) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]