≡

Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2)

[Edit]

ALR; MLL4; HRX2; TRX2; WBP7; KMT2D; AAD10; TNRC21; Trinucleotide Repeat Containing 21; ALL1-related protein; Histone-lysine N-methyltransferase 2D

Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2)
CCC L737
HGNC 7133
MGI 2682319
PubMed 23913813
UniProt O14686
Wiki MLL2
MLL2 is a striking example with 24 amino acid runs, all but 2 of which are glutamine runs. The gene encodes a 5,262-amino acid protein containing a SET domain, 5 PHD fingers, potential zinc fingers, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine). They also detected an alternatively spliced form encoding 4,957 amino acids and lacking an N-terminal zinc finger and PHD finger.
Analysis of ALR expression showed that its approximately 18-kb transcript is expressed, like ALL1, in most adult tissues, including a variety of hematopoietic cells, but not in liver. Whole mount in situ hybridization of early mouse embryos indicated expression of a similar mouse gene in multiple tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 2 (MLL2) ELISA Kit Customized Service Offer
  1. "Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax."Oncogene 15:549-560(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins."Mol. Cell. Biol. 23:140-149(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the MLL2 complex as a coactivator for estrogen receptor alpha."J. Biol. Chem. 281:15714-15720(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases."Proc. Natl. Acad. Sci. U.S.A. 103:15392-15397(2006) [PubMed] [Europe PMC] [Abstract]
  7. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A histone H3 lysine 27 demethylase regulates animal posterior development."Nature 449:689-694(2007) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination."Science 318:447-450(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "MLL2 mutation spectrum in 45 patients with Kabuki syndrome." Hum. Mutat. 32:E2018-E2025(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome." Nat. Genet. 42:790-793(2010) [PubMed] [Europe PMC] [Abstract]