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Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3)

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HALR; KMT2C; Homologous to ALR protein; Histone-lysine N-methyltransferase 2C

Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3)
CCC L738
HGNC 13726
MGI 2444959
PubMed 24081332
UniProt Q8NEZ4
Wiki MLL3
MLL3 is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus; a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region; and 2 C-terminal FY (phe-tyr) motifs and a SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 3 (MLL3) ELISA Kit Customized Service Offer
  1. "MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia."Gene 284:73-81(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects."Cancer Detect. Prev. 25:454-469(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins."Mol. Cell. Biol. 23:140-149(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases."Proc. Natl. Acad. Sci. U.S.A. 103:15392-15397(2006) [PubMed] [Europe PMC] [Abstract]
  10. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the first and second PHD domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog."Submitted (OCT-2007) to the PDB data bank
  17. "Solution structure of the HMG box of human myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog."Submitted (APR-2008) to the PDB data bank
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]