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Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4)

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AF-6; AF6; Afadin; ALL1-fused gene from chromosome 6 protein

Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4)
CCC L742
HGNC 7137
MGI 1314653
PubMed 20545580
RGD 708561
UniProt P55196
Wiki MLLT4
AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t(6;11) translocations.
The gene, designated AF6 by them, was found to be expressed in a variety of cell types and to encode a protein of 1,612 amino acids. The protein contains short stretches rich in proline, charged amino acids, serines, or glutamines. In addition, the AF6 protein contains the GLGF motif shared with several proteins of vertebrates and invertebrates thought to be involved in signal transduction at special cell-cell junctions.Mutation analysis indicated that the GTP-Ras-interacting domain was between amino acids 36 and 206 of bovine Af6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia Translocated To 4 (MLLT4) ELISA Kit Customized Service Offer
  1. "Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation."Cancer Res. 53:5624-5628(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene."DNA Res. 5:115-120(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin."Gene 255:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Nectin and afadin: novel organizers of intercellular junctions."J. Cell Sci. 116:17-27(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr."J. Biol. Chem. 280:13841-13847(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Discovery of low-molecular-weight ligands for the AF6 PDZ domain."Angew. Chem. Int. Ed. 45:3790-3795(2006) [PubMed] [Europe PMC] [Abstract]