≡

Myxovirus Resistance 2 (MX2)

[Edit]

MXB; Interferon-Regulated Resistance GTP-Binding Protein MXB; Second Interferon-Induced Protein p78

Myxovirus Resistance 2 (MX2)
CCC L764
HGNC 7533
PubMed 24048477
UniProt P20592
Wiki MX2
MX2 has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon.
This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.the 2 Mx mRNAs that they isolated are distinct. Southern blot analysis of mouse-human cell hybrid DNA indicated that both are located on chromosome 21. The mouse Mx gene is located on the distal part of chromosome 16 in the region of genetic homology to human chromosome 21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL764Hu01 Recombinant Myxovirus Resistance 2 (MX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL764Hu21 Monoclonal Antibody to Myxovirus Resistance 2 (MX2) WB; IHC; ICC; IP.
PAL764Hu01 Polyclonal Antibody to Myxovirus Resistance 2 (MX2) WB; IHC; ICC; IP.
MAL764Hu22 Monoclonal Antibody to Myxovirus Resistance 2 (MX2) WB; IHC; ICC; IP.
MAL764Hu23 Monoclonal Antibody to Myxovirus Resistance 2 (MX2) WB; IHC; ICC; IP.
Assay Kits SEL764Hu ELISA Kit for Myxovirus Resistance 2 (MX2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA structures and regulation of two interferon-induced human Mx proteins."Mol. Cell. Biol. 9:5062-5072(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter."J. Virol. 64:1171-1181(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB."Proc. Natl. Acad. Sci. U.S.A. 101:8957-8962(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Mx GTPase family of interferon-induced antiviral proteins."Microbes Infect. 9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Dynamins are forever: MxB inhibits HIV-1."Cell Host Microbe 14:371-373(2013) [PubMed] [Europe PMC] [Abstract]
  10. "The interferon-inducible MxB protein inhibits HIV-1 infection."Cell Host Microbe 14:398-410(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection."Nature 502:559-562(2013) [PubMed] [Europe PMC] [Abstract]
  12. "MX2 is an interferon-induced inhibitor of HIV-1 infection."Nature 502:563-566(2013) [PubMed] [Europe PMC] [Abstract]